Statistically, Tua puts up similar to better numbers when Tyreek is off the field. This team was transitioning to the offense running through Achane. I believe they have the receivers to spread the ball around and obviously Waller looks like he's going to be a go-to guy on 3rd downs and in the red zone now. Run the ball, read option, play action, bootlegs.
Frankly I expect it to be a lot like last year when he missed a fair amount of time and was injured and ineffective when on the field. More commitment to the running game, more use of TEs (namely Waller), Malik taking a bigger role.