God of War III The reason is God of War I was amazingly super awesome and God of War II was amazingly super crazily mega awesome.
I voted Red Dead Redemption... ONLY because I have Mass Effect 2 already. It would definitely have been ME2 otherwise. Most of the stuff on that list I'm drooling over. Top of the list being Starcraft II, Bioshock 2, and Mario Galaxy 2. Bottom of the list goes to Metroid, Castlevania, and Halo Reach.
mass effect 2. I have most of the other stuff preordered, and im definitely excited for most of them, but mass effect is a guaranteed 2-3 play throughs. I also loved Mario Galaxy. 2nd favorite game this gen. I will be absolutely stoked for that in 2 months when i've finally gotten mass effect out of my system.
not sure I have a MOST anticipated game. I'm looking forward to most of those. I gave my point to Halo, though, since I've been playing those games the longest and they seem to have the longest lifespan for me.
FFXIII is my most anticipated. Gran Turismo 5 and Halo Reach, are up there as well. ME2 would be #2 but it's out next week.