http://news.aol.com/story/_a/man-survives-a-nailgun-shot-to-the-head/20080611094709990001
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Well, you can barely notice it.
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Phinneaus Gage was the first well documented case of this type of injury. He was involved in a railroad tie accident. Went through his skull. The most noticable effect was a change in personality. Psychologists study these people in order to better understand the brain and its functioning.