If the oddsmakers are to be believed, however, this game will also not end up positively for the home team. According to the opening odds over at DraftKings Sportsbook, the Patriots are 2.5-point underdogs to the Dolphins. The over/under for the game has been set at 47. Miami is -135 on the moneyline, while New England is +110. New England being listed as underdogs is no surprise. Not only did they lose their Week 1 game, the Dolphins also won theirs in impressive fashion: behind a 466-yard effort from quarterback Tua Tagovailoa, Miami beat the Los Angeles Chargers (-3) The game between the Patriots and Dolphins is scheduled for an 8:20 p.m. ET kickoff on Sunday, Sep. 17.