They can't and that's going to be a huge problem. I actually think they should go in a different direction with the movie, much like Dupree said. Turn it into an action or horror film instead, even though stuff like the basic plot has happened before in films.
If they wanted to keep it as a comedy I could see Jason Segal as Gilligan and Paul Rudd as the Professor, but make that character extremely sarcastic. Michael Caine would be a pretty good Mr. Howell but he might be too old for that now.
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